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The project is collecting and analyzing MRI, fMRI, DTI, EEG, and MEG data to study language function. We have designed and tested custom data acquisition paradigms for the functional mapping of language—intended for use in both non-invasive and invasive technologies. We have collaborated closely with Dr Steve Stufflebeam, the director of the MEG laboratory at MGH, designing, testing, and implementing data acquisition protocols for the collection of non-invasive functional EEG and MEG data. We have collected and analyzed language fMRI data on approximately 14 normal volunteers, and 4 patients. We have also collected and analyzed language MEG in approximately 8 normal volunteers, and 2 patients. From these data, we have submitted abstracts for 3 scientific poster presentations, all of which were accepted for presentation. Including the Winner of 2005 Excellence Award, 2005 M.E.G. Clinical Applications Conference, Xylocastro, Greece.


Figure 1. In this figure blue models represent MEG language localizations, red models represent fMRI language localizations, brown cords represent white matter tractography by DTI, yellow models represent MEG interictal discharge foci, the green modelrepresents a tumor lesion, and the red tags represent intra-operative language mapping sites ascertained by intra-operativetesting in the operating room. The results illustrated in these two patients represent state-of-the-art visualization and integration of a wide variety of functional and structural imaging techniques.


Figure 2. (left) Anatomic MR images demonstrate a large left temporal lesion. (right) Functional MRI demonstrates language-associated activations.


Figure 3. (left) Intra-operative neuronavigation GE InstaTrak screenshot: left-temporal mass lesion (yellow); fMRI activation (blue); electrode sites (yellow dots); negative ECS sites (green dots); and positive ECS sites (red dots). (right) 3D Slicer software screenshot for offline comparative analysis of intrao-perative ECS language testing sites and pre-operative fMRI language function: left-temporal lesion (green); fMRI activation (blue); electrode strips (yellow dots); negative ECS sites (green dots); and positive ECS sites (red dots).

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GOLBY LAB
Department of Neurosurgery
Brigham and Women’s Hospital
Hale Building for Transformative Medicine
60 Fenwood Road, 8th Floor
Boston, MA 02115

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