Golby Lab, A Surgical Brain Mapping Laboratory
golby Golby Lab, A
              Surgical Brain Mapping Laboratory
Golby Lab
                Research Fund

New Book:

Image-Guided Neurosurgery

Edited by

  • Alexandra Golby, MD
Image-Guided Neurosurgery

About the book: Throughout its history, the field of neurosurgery has been revolutionized by improvements in imaging and visualization.  From the development of the pneumoencephalogram, to the operating microscope, to cross sectional imaging with CT and later MRI, to stereotaxy and neuronavigation, the ability to visualize the pathology and surrounding neural structures has been the driving factor leading surgical innovation and improved outcomes.  The last decade has seen perhaps the greatest impact of imaging in neurosurgery.  Several examples include the ubiquitous use of neuronavigation in cranial surgery, the increasing adoption of intra-operative MRI, and the development of numerous devices designed to harness these advances for better patient care.  Image-Guided Neurosurgery is a comprehensive reference on the application of contemporary imaging technologies used in neurosurgery. Specific techniques will be discussed for brain biopsies, brain tumor resection, deep brain stimulation, and more.Image-Guided Neurosurgery is written for neurosurgeons, interventional radiologists, neurologists, psychiatrists, and radiologists, as well as technical experts in imaging, image analysis, computer science, and biomedical engineering.

Publications 2007 - Present

  1. Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma. Neuro Oncol. 2015 Mar 9. pii: nov015. [Epub ahead of print]
  2. "Extraoperative" MRI (eoMRI) for Brain Tumor Surgery: Initial Results at a Single Institution. World Neurosurg. 2015 Jun;83(6):921-8. doi: 10.1016/j.wneu.2015.02.002. Epub 2015 Feb 17.
  3. Atypical presentation of cerebral schistosomiasis four years after exposure to Schistosoma mansoni. Epilepsy Behav Case Rep. 2014 Feb 11;2:80-5.
  4. smart stylet: the development and use of a bedside external ventricular drain image-guidance system. Stereotact Funct Neurosurg. 2015;93(1):50-8. doi: 10.1159/000368906. Epub 2015 Jan 31.
  5. Comparison of seeding methods for visualization of the corticospinal tracts using single tensor tractography. Clin Neurol Neurosurg. 2015 Feb;129:44-9.
  6. Multimodal imaging for improved diagnosis and treatment of cancers. Cancer. 2015 Mar 15;121(6):817-27. doi: 10.1002/cncr.29012. Epub 2014 Sep 9. Review.
  7. Decoupling function and anatomy in atlases of functional connectivity patterns: language mapping in tumor patients. Neuroimage. 2014 Dec;103:462-75.
  8. Comparative effectiveness of frame-based, frameless, and intraoperative magnetic resonance imaging-guided brain biopsy techniques. World Neurosurg. 2015 Mar;83(3):261-8.
  9. Local control after fractionated stereotactic radiation therapy for brain metastases. J Neurooncol. 2014 Nov;120(2):339-46. doi: 10.1007/s11060-014-1556-5. Epub 2014 Jul 25.
  10. Defining language networks from resting-state fMRI for surgical planning--a feasibility study. Hum Brain Mapp. 2014 Mar;35(3):1018-30.
  11. Fiber clustering versus the parcellation-based connectome. Neuroimage. 2013 Oct 15;80:283-9
  12. Extended Broca's area in the functional connectome of language in adults: combined cortical and subcortical single-subject analysis using fMRI and DTI tractography. Brain Topogr. 2013 Jul;26(3):428-41.
  13. Effect of disease and recovery on functional anatomy in brain tumor patients: insights from functional MRI and diffusion tensor imaging. Imaging Med. 2013 Aug 1;5(4):333-346.
  14. Neuronavigation in the surgical management of brain tumors: current and future trends. Expert Rev Med Devices. 2012 Sep;9(5):491-500.
  15. fMRI-DTI modeling via landmark distance atlases for prediction and detection of fiber tracts. Neuroimage. 2012 Mar;60(1):456-70. Epub 2011 Dec 2.
  16. Learning an atlas of a cognitive process in its functional geometry.Inf Process Med Imaging. 2011;22:135-46.
  17. Visual Pathway Study Using in vivo DTI Tractography to Complement Classical Anatomy. Neurosurgery. 2011 Jul 29.
  18. Development of a clinical functional magnetic resonance imaging service. Neurosurg Clin N Am. 2011 Apr;22(2):307-14
  19. Special surgical considerations for functional brain mapping. Neurosurg Clin N Am. 2011 Apr;22(2):111-32
  20. Intraoperative real-time querying of white matter tracts during frameless stereotactic neuronavigation. Neurosurgery. 2011 Feb;68(2):506-16
  21. Interactive Diffusion Tensor Tractography Visualization for Neurosurgical Planning. Neurosurgery. 2011 Feb;68(2):496-505.
  22. A combined fMRI and DTI examination of functional language lateralization and arcuate fasciculus structure: Effects of degree versus direction of hand preference. Brain Cogn. 2010 Jul;73(2):85-92.
  23. The fiber laterality histogram: a new way to measure white matter asymmetry.Med Image Comput Comput Assist Interv. 2010;13(Pt 2):225-32.
  24. An intraoperative brain shift monitor using shear mode transcranial ultrasound: preliminary results. J Ultrasound Med. 2009 Feb;28(2):191-203.
  25. Tract-based morphometry for white matter group analysis. Neuroimage. 2008 Dec 25. [Epub ahead of print]
  26. Comparison of blocked and event-related fMRI designs for pre-surgical language mapping. Neuroimage. 2008 Dec 6. [Epub ahead of print]
  27. Resolving crossings in the corticospinal tract by two-tensor streamline tractography: Method and clinical assessment using fMRI. Neuroimage. 2008 Jul 8. [Epub ahead of print]
  28. Group independent component analysis of language fMRI from word generation tasks. Neuroimage. 2008 Sep 1;42(3):1214-25.
  29. Fieldmap-Free Retrospective Registration and Distortion Correction for EPI-Based Functiona Imaging. Int Conf Med Image Comput Comput Assist Interv. 2008;11(Pt 2):271-279.
  30. Images of Restricted Water in Brain with Applications to Neurosurgery. Abstract, Intl Soc Mag Reson Med 2008
  31. Quantification of white matter fiber orientation at tumor margins with diffusion tensor invariant gradients. Proc Intl Soc Mag Reson Med 2008
  32. Identification of essential language areas by combination of fMRI from different tasks using probabilistic independent component analysis. Proceedings of the 2nd International Conference on Bioinformatics and Biomedical Engineering, iCBBE2008
  33. Clinical Functional Magnetic Resonance Imaging and Diffusion Tensor Imaging for Surgical Planning. Tutorial at the First annual NIH-sponsored Image-Guided Interventions Workshop 2008 March
  34. Distortion reduction in EPI based on minimal FOV. Abstract #3721, Intl Soc Mag Reson Med 2007
  35. Tract-Based Morphometry. Int Conf Med Image Comput Comput Assist Interv. 2007;10(Pt 2):161-168
  36. Compensation of geometric distortion effects on intra-operative MRI for enhanced visualization in image-guided neurosurgery. Neurosurgery. August, 2007, [in press].

    Click here to view this article as a PDF
  37. Object naming is a more sensitive measure of speech localization than number counting: Converging evidence from direct cortical stimulation and fMRI. Neuroimage, 37(1, Suppl 1), 100-108, 2007.

    Click here to view this article as a PDF
  38. Quantitative comparison of functional MRI and direct electrocortical stimulation for functional mapping. Int J Med Robot. 2007 Aug 31; [Epub ahead of print]
  39. Rater-dependent accuracy in predicting the spatial location of functional centers on anatomical MR images. Clin Neurol Neurosurg. 2007 Apr;109(3):225-35. Epub 2006 Sep 29.
  40. Non-rigid alignment of pre-operative MRI, fMRI, and DT-MRI with intra-operative MRI for enhanced visualization and navigation in image-guided neurosurgery. Neuroimage. 2007 Apr 1;35(2):609-24. Epub 2006 Dec 23.

    Click here to view this article as a PDF
  41. Functional brain mapping and its applications to neurosurgery. Neurosurgery. 2007; 60(4, Suppl 2), 185-201.

    Click here to view this article as a PDF.