Golby Lab, A Surgical Brain Mapping Laboratory
Golby Lab Research Fund
People

Multi-modality Language mapping

The project is collecting and analyzing MRI, fMRI, DTI, EEG, and MEG data to study language function. We have designed and tested custom data acquisition paradigms for the functional mapping of language—intended for use in both non-invasive and invasive technologies. We have collaborated closely with Dr Steve Stufflebeam, the director of the MEG laboratory at MGH, designing, testing, and implementing data acquisition protocols for the collection of non-invasive functional EEG and MEG data. We have collected and analyzed language fMRI data on approximately 14 normal volunteers, and 4 patients. We have also collected and analyzed language MEG in approximately 8 normal volunteers, and 2 patients. From these data, we have submitted abstracts for 3 scientific poster presentations, all of which were accepted for presentation. Including the Winner of 2005 Excellence Award, 2005 M.E.G. Clinical Applications Conference, Xylocastro, Greece.

Intra-operative use at BWH of fMRI and ECS brain mapping for localization of eloquent cortex
Figure 1. In this figure blue models represent MEG language localizations, red models represent fMRI language
localizations, brown cords represent white matter tractography by DTI, yellow models represent MEG interictal discharge
foci, the green modelrepresents a tumor lesion, and the red tags represent intra-operative language mapping sites
ascertained by intra-operativetesting in the operating room. The results illustrated in these two patients represent
state-of-the-art visualization and integration of a wide variety of functional and structural imaging techniques.


Intra-operative use at BWH of fMRI and ECS brain mapping for localization of eloquent cortex
Figure 2. (left) Anatomic MR images demonstrate a large left temporal lesion.
(right) Functional MRI demonstrates language-associated activations.


Intra-operative use at BWH of fMRI and ECS brain mapping for localization of eloquent cortex
Figure 3. (left) Intra-operative neuronavigation GE InstaTrak screenshot: left-temporal mass lesion (yellow); fMRI activation (blue);
electrode sites (yellow dots); negative ECS sites (green dots); and positive ECS sites (red dots). (right) 3D Slicer software screenshot
for offline comparative analysis of intrao-perative ECS language testing sites and pre-operative fMRI language function: left-temporal
lesion (green); fMRI activation (blue); electrode strips (yellow dots); negative ECS sites (green dots); and positive ECS sites (red dots).